Highlight report: gene dose response in N-acetylation capacity

Highlight report: Cardiotoxicity screening

have published a review about identification of cardiotoxic compounds by rapid screening methods (Li et al., 2015). Cardiotoxicity is one of the most frequent causes for withdrawal of drugs from the market and also during drug development (MacDonald and Robertson, 2009; Apostolakis et al., 2013; Li et al., 2015). Totally, 81 drugs have been taken from the market between 1990 and 2013 (Li et al....

NEUROGENIC HYPERTENSION: REPORT OF FIVE CASES TO HIGHLIGHT THE CONTROVERSY

The entity of "neurogenic hypertension" is defined as arterial hypertension caused explicitly by derangement of the intricate network of the central nervous system. Among 193 cases of cranial rhizopathies operated on between 1984 and 1995 at this center, 5 cases of established arterial hypertension with concomitant rhizopathies also underwent ventrolateral medullary decompression. The elev...

Highlight report: The pseudolobule in liver fibrosis

Recently, Seddik Hammad from Heidelberg University published an interesting report about a frequent misinterpretation in research on liver fibrosis (Hammad et al., 2017): in mice repeated doses of carbontetrachloride (CCl4) cause a pattern of fibrosis, in which pseudolobules occur that are lined by fibrotic streets, which can be visualized by Sirius red staining. In the center of these pseudolo...

Highlight report: Metabolomics in hepatotoxicity testing

S-N transfer and dual acetylation in the S-acetylation and N-acetylation of 3-phosphoglyceraldehyde dehydrogenase by substrates.

7. FUWA, K., WACKER, W. E. C., DRUYAN, R., BARTHOLOMY, A. F., AND VALLEE, B. L., Proc. Katl. Acad. Sci. U. S., 46, 1198 (1960). MAHLER, H. R., DUTTON, G., AND MEHROTRA, B. D., Biochim. et Btiphys. Acta, 68, 199 (1963). 8. 9. FRESCO, J. R., ALBERT, B. M., AND DOTY, P., Nature, 188, 98 (1960). BRUNNGRABER, E. F., Biochem. and Biophys. Research Communs., 8, 1 (1962). 10. VON EHRENSTEIN,G., AND LIP...